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. There are 2 unique clades from the virus: clade I (with subclades Ia and Ib) and clade II (with subclades IIa and IIb). In 2022–2023 a world outbreak of mpox was due to the clade IIb pressure. WHO is effective with Member States and partners to prevent and reply to outbreaks of mpox. This involves coordinating investigation on vaccines and sol